Advanced Search
MyIDEAS: Login to save this paper or follow this series

Modeling Plasma Virus Concentration and CD4+ T Cell Kinetics during Primary HIV Infection

Contents:

Author Info

  • Max A. Stafford
  • Yunzhen Cao
  • David D. Ho
  • Lawrence Corey
  • Crystal L. Mackall
  • Ronald E. Gress
  • Alan S. Perelson
Registered author(s):

    Abstract

    During primary HIV infection the viral load in plasma increases, reaches a peak, and then declines. Phillips has suggested that the decline is due to a limitation in the number of cells susceptible to HIV infection, while other authors have suggested that the decline in viremia is due to an immune response. Here we address this issue by developing models of primary HIV-1 infection, which include T cell kinetics, and by comparing predictions from these models with data from nine, anti-retroviral drug-naive infected patients. Applying nonlinear least squares estimation, we find that relatively small variations in parameters are capable of mimicking the highly diverse patterns found in patient viral load data. This approach yields an estimate of two days for the lifespan of productively infected cells during primary infection, a value that is consistent with results obtained by drug perturbation experiments. We find that all patient data sets considered are consistent with a target-cell limited model from the time of initial infection until shortly after the peak in viremia, but some data sets are not consistent after the peak value with the assumptions of such a model. We illustrate that two possible immune response mechanisms, cytotoxic T lymphocyte destruction of infected target cells and cytokine suppression of viral replication, could account for declines in viral load data not predicted by the original target-cell limited model. We conclude that some additional process, perhaps mediated by CD8+ T cells, is important in at least some patients. Submitted to J. Theor. Biol.

    Download Info

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below under "Related research" whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a search for a similarly titled item that would be available.

    Bibliographic Info

    Paper provided by Santa Fe Institute in its series Working Papers with number 99-05-036.

    as in new window
    Length:
    Date of creation: May 1999
    Date of revision:
    Handle: RePEc:wop:safiwp:99-05-036

    Contact details of provider:
    Postal: 1399 Hyde Park Road, Santa Fe, New Mexico 87501
    Web page: http://www.santafe.edu/sfi/publications/working-papers.html
    More information through EDIRC

    Related research

    Keywords: Math models; CD4+ T cells; HIV; HIV dynamics; primary HIV-1 infection; immune system; CTL; CAF;

    Find related papers by JEL classification:

    This paper has been announced in the following NEP Reports:

    References

    References listed on IDEAS
    Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
    as in new window
    1. Ashley T. Haase & Keith Henry & Mary Zupancic & Gerlad Sedgewick & Russell A. Faust & Holly Melroe & Winston Cavert & Kristin Gebhard & Katherine Staskus & Zhi-Qiang Zhang & Peter J. Dailey & Henry H., 1996. "Quantitative Image Analysis of HIV-1 Infection in Lymphoid Tissue," Working Papers 96-07-045, Santa Fe Institute.
    Full references (including those not matched with items on IDEAS)

    Citations

    Lists

    This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.

    Statistics

    Access and download statistics

    Corrections

    When requesting a correction, please mention this item's handle: RePEc:wop:safiwp:99-05-036. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Thomas Krichel).

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If references are entirely missing, you can add them using this form.

    If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.