Mutational Robustness and Asymmetric Functional Specialization of Duplicate Genes
AbstractMost duplicate genes are eliminated from a genome shortly after duplication, but those that remain are an important source of biochemical diversity. Much of their diversification arises via functional ÒspecializationÓ, loss of some functions of the duplicates remaining in the genome. I here present evidence from genome-scale protein-protein interaction data, microarray expression data, and large-scale gene knockout data that this diversification is often asymmetrical: one duplicate usually shows significantly more molecular or genetic interactions than the other. I propose a model that can explain this divergence pattern if duplicate gene pairs are less likely to suffer deleterious mutations when having diverged asymmetrically. The data may provide the first evidence that natural selection has increased mutational robustness in genetic networks.
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Bibliographic InfoPaper provided by Santa Fe Institute in its series Working Papers with number 02-02-006.
Date of creation: Feb 2002
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Molecular evolution; protein networks; micro array; robustness;
This paper has been announced in the following NEP Reports:
- NEP-ALL-2002-04-15 (All new papers)
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