Most duplicate genes are eliminated from a genome shortly after duplication, but those that remain are an important source of biochemical diversity. Much of their diversification arises via functional ÒspecializationÓ, loss of some functions of the duplicates remaining in the genome. I here present evidence from genome-scale protein-protein interaction data, microarray expression data, and large-scale gene knockout data that this diversification is often asymmetrical: one duplicate usually shows significantly more molecular or genetic interactions than the other. I propose a model that can explain this divergence pattern if duplicate gene pairs are less likely to suffer deleterious mutations when having diverged asymmetrically. The data may provide the first evidence that natural selection has increased mutational robustness in genetic networks.
Download Info
To our knowledge, this item is not available for
download. To find whether it is available, there are three
options:
1. Check below under "Related research" whether another version of this item is available online.
2. Check on the provider's web page
whether it is in fact available.
3. Perform a search for a similarly titled item that would be
available.
Publisher Info
Paper provided by Santa Fe Institute in its series Working Papers with number
02-02-006.
Did you know? Citation analysis on IDEAS includes online papers that are freely accessible and whose text could be automatically analyzed, currently about 150000 papers.