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Evolution in Systems of Ligation-Based Replicators

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Author Info
Bårbel M. R. Stadler
Peter F. Stadler
Peter R. Wills
Abstract

The population dynamics of macromolecules that reproduce by means of template-directed ligation of two fragments are shown to be represented by a replicator equation with a special non-linear response function. This result is obtained through detailed consideration of the mechanism of ligation autocatalysis. In contrast to treatments which involve simplification to a parabolic growth law and the expectation of global coexistence of all species, we find that strong selection can take place in such systems, even when there is slow uncatalysed synthesis of replicators. Also, systems of this type are subject to invasion by new species that have a selective advantage. An expression is derived for the survival threshold in terms of species parameters and it is shown that this threshold depends on the total concentration of all species in the system. For a plausible distribution of species parameters, the number of surviving species coexisting above the threshold increases monotonically with increasing concentration. Illustrative numerical simulations are presented.

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Paper provided by Santa Fe Institute in its series Working Papers with number 01-09-052.

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Date of creation: Sep 2001
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Handle: RePEc:wop:safiwp:01-09-052

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Related research
Keywords: Autocatalytic reaction networks; parabolic growth; extinction threshold; metadynamics;

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Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
  1. W. Fontana & P. Schuster, 1998. "Continuity in Evolution: On the Nature of Transitions," Working Papers ir98039, International Institute for Applied Systems Analysis. [Downloadable!]
  2. BŠrbel M. R. Stadler & Peter F. Stadler & GŸnter P. Wagner & Walter Fontana, 2000. "The Topology of the Possible: Formal Spaces Underlying Patterns of Evolutionary Change," Working Papers 00-12-070, Santa Fe Institute.
  3. Walter Fontana & Peter Schuster, 1998. "Continuity in Evolution: On the Nature of Transition," Working Papers 98-04-030, Santa Fe Institute.
  4. W. Fontana & P. Schuster, 1998. "Shaping Space: The Possible and the Attainable in RNA Genotype-Phenotype Mapping," Working Papers ir98004, International Institute for Applied Systems Analysis. [Downloadable!]
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