Advanced Search
MyIDEAS: Login

Inferring Life Style From Gene Expression Patterns

Contents:

Author Info

  • Andreas Wagner
Registered author(s):

    Abstract

    For many organisms, and especially for the model organisms of molecular and cell biology, the primary locus of study is the laboratory, and not their natural habitat. Thus, a huge body of knowledge accumulated through a century of laboratory studies contrasts with the limited amount of information available on the ecology of many model organisms. This discrepancy is particularly through a century of laboratory studies contrasts with the limited amount of information available on the ecology of many model organisms. This discrepancy is particularly striking for microbes, which arguably provide the bulk of our cell biological knowledge, but whose natural habitats are poorly understood. Their physiology, their genomic gene content, and the sturcture of their genetic networks has been shaped over millions of years by natural selection in the wild. Because of this discrepancy, certain laboratory experiments have limited value in understanding the workings of an organism. A case in point are the huge number of gene knock-out experiments in multiple eukaryotes that show little or no phenotypic effects in the laboratory. The artifical conditions under which these experiments are carried out may sometimes be resonsible for the absence of such phenotypic defects. Arguably, in the wild, such knock-out mutations might be elimited form the population. It would thus be best to assay their effects under more realistic conditions.

    Download Info

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below under "Related research" whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a search for a similarly titled item that would be available.

    Bibliographic Info

    Paper provided by Santa Fe Institute in its series Working Papers with number 00-02-014.

    as in new window
    Length:
    Date of creation: Feb 2000
    Date of revision:
    Handle: RePEc:wop:safiwp:00-02-014

    Contact details of provider:
    Postal: 1399 Hyde Park Road, Santa Fe, New Mexico 87501
    Web page: http://www.santafe.edu/sfi/publications/working-papers.html
    More information through EDIRC

    Related research

    Keywords: Microarrays; life history; codon bias.;

    This paper has been announced in the following NEP Reports:

    References

    No references listed on IDEAS
    You can help add them by filling out this form.

    Citations

    Lists

    This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.

    Statistics

    Access and download statistics

    Corrections

    When requesting a correction, please mention this item's handle: RePEc:wop:safiwp:00-02-014. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Thomas Krichel).

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If references are entirely missing, you can add them using this form.

    If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.