IDEAS home Printed from https://ideas.repec.org/p/oec/envaad/9-en.html
   My bibliography  Save this paper

Adverse Outcome Pathway on Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)

Author

Listed:
  • Daniel L. Villeneuve

    (US Environmental Protection Agency (EPA))

Abstract

This AOP details the linkage between binding and activation of androgen receptor (AR) in females and reductions in cumulative fecundity and spawning. AR-mediated activities are among the major concerns in endocrine disruptor screening programs. Cumulative fecundity is the apical endpoint considered in the OECD 229 Fish Short Term Reproduction Assay. It is also one of several variables with demographic significance in forecasting fish population trends. Therefore, this AOP supports the use of measures of AR activation as a means to identify chemicals with potential to adversely affect fish populations. At present, this AOP is largely supported by evidence from small laboratory model fish species. While many aspects of the biology underlying this AOP are largely conserved across oviparous vertebrates, its relevance to vertebrate classes other than fish, or to fish species employing different reproductive strategies has not been established. Thus, the applicability domain should be carefully considered when evaluating fit-for-purpose.

Suggested Citation

  • Daniel L. Villeneuve, 2018. "Adverse Outcome Pathway on Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)," OECD Series on Adverse Outcome Pathways 9, OECD Publishing.
    • Handle: RePEc:oec:envaad:9-en
    DOI: 10.1787/b0c6838a-en
    as

    Download full text from publisher

    File URL: https://doi.org/10.1787/b0c6838a-en
    Download Restriction: no
    File URL: https://libkey.io/10.1787/b0c6838a-en?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:oec:envaad:9-en. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: the person in charge (email available below). General contact details of provider: https://edirc.repec.org/data/enoecfr.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.