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Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis

Author

Listed:
  • Sabina Halappanavar
  • Monita Sharma
  • Silvia Solorio-Rodriguez
  • Hakan Wallin
  • Ulla Vogel
  • Kristie Sullivan
  • Amy J. Clippinger

Abstract

Lung fibrosis is a dysregulated or exaggerated tissue repair process resulting in the thickening or scarring of lung tissue. It involves the presence of sustained or repeated exposure to a stressor and intricate dynamics between several inflammatory and immune response cells, and the microenvironment of the alveolar-capillary region consisting of both immune and non-immune cells, and the lung interstitium. This AOP is applicable to a broad group of stressors of diverse properties e.g. metal dusts, pharmacological products, fibres, microorganisms, chemicals, including novel technology-enabled stressors such as nanomaterials. This AOP is referred to as AOP 173 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki).

Suggested Citation

  • Sabina Halappanavar & Monita Sharma & Silvia Solorio-Rodriguez & Hakan Wallin & Ulla Vogel & Kristie Sullivan & Amy J. Clippinger, 2023. "Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis," OECD Series on Adverse Outcome Pathways 33, OECD Publishing.
    • Handle: RePEc:oec:envaad:33-en
    DOI: 10.1787/10372cb8-en
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