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Inhibitor binding to topoisomerase II leading to infant leukaemia

Author

Listed:
  • Olavi Pelkonen
  • Andrea Terron
  • Antonio F. Hernandez
  • Pablo Menendez
  • Susanne Hougaard Bennekou

Abstract

This Adverse Outcome Pathway (AOP) describes the linkages between the perturbation of the normal topoisomerase II enzyme function and infant leukaemia. Infant leukaemia is a rare haematological disease (1 in 106 newborns, accounting for 10% of all childhood acute lymphoblastic leukaemias) of developmental origin, manifesting soon after birth (

Suggested Citation

  • Olavi Pelkonen & Andrea Terron & Antonio F. Hernandez & Pablo Menendez & Susanne Hougaard Bennekou, 2022. "Inhibitor binding to topoisomerase II leading to infant leukaemia," OECD Series on Adverse Outcome Pathways 21, OECD Publishing.
    • Handle: RePEc:oec:envaad:21-en
    DOI: 10.1787/4782fbfc-en
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