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Methotrexate treatment for ectopic pregnancy after assisted reproductive ă technology: A case-control study

Author

Listed:
  • A. Ohannessian
  • P. Crochet
  • B. Courbiere

    (Service de Gynécologie et Obstétrique [Marseille] - LA CONCEPTION - Hôpital de la Conception [CHU - APHM], IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale - AU - Avignon Université - AMU - Aix Marseille Université - Institut de recherche pour le développement [IRD] : UMR237 - CNRS - Centre National de la Recherche Scientifique)

  • A. Gnisci
  • A. Agostini

    (Dipartimento di Matematica e Fisica - ROMA TRE - Università degli Studi Roma Tre = Roma Tre University)

Abstract

Objectives. - Ectopic pregnancy (EP) occurs in 2% to 5.6% of ă pregnancies achieved by assisted reproductive technology (ART). EP ă treatment options include medical treatment by uses of methotrexate ă (MTX) systemic injection. The objective of this study was to compare MTX ă treatment effectiveness for EP occurring spontaneously or following ART. ă Methods. - A case-control study performed in the department of ă obstetrics and gynecology at a tertiary health care center in France. ă Twenty EP achieved by ART (ART group) and 60 spontaneous EP (SEP group) ă received MTX treatment between January 2002 and May 2012. The main ă outcome measures were MTX treatment failure rates, number of MTX ă injections administered and recovery time. ă Results. - MTX treatment failure rates observed in ART and SEP groups ă were similar (3/20 [15%] versus 10/60 [17%]: OR = 0.88 ă [0.22-3.58]). Mean duration of recovery time in patients with ă successful MTX treatment did not differ between ART and SEP groups (33 ă 14 days versus 28 13 days, P = 0.39). A second MTX injection was ă required more frequently in ART group than in SEP group (10/20 [50%] ă versus 10/60 [17%]: OR= 5 [1.65-15.15]). ă Conclusions. - It is concluded that MTX treatment is equally effective ă for spontaneous EP and EP achieved by ART, two injections of MTX being ă more frequently required in case of ART. (C) 2016 Elsevier Masson SAS. ă All rights reserved.

Suggested Citation

  • A. Ohannessian & P. Crochet & B. Courbiere & A. Gnisci & A. Agostini, 2016. "Methotrexate treatment for ectopic pregnancy after assisted reproductive ă technology: A case-control study," Post-Print hal-01482528, HAL.
    • Handle: RePEc:hal:journl:hal-01482528
    DOI: 10.1016/j.gyobfe.2016.04.004
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