Advanced Search
MyIDEAS: Login

A case-only approach for assessing gene-sex interaction in human longevity

Contents:

Author Info

  • Qihua Tan

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Anatoli I. Yashin

    (Max Planck Institute for Demographic Research, Rostock, Germany)

  • Else M. Bladbjerg
  • Moniek De Maat
  • Karen Andersen-Ranberg
  • Bernard Jeune
  • Kaare Christensen
  • James W. Vaupel

    (Max Planck Institute for Demographic Research, Rostock, Germany)

Registered author(s):

    Abstract

    As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing gene-sex interaction are expected. New and valid statistical methods are needed. In this paper, we introduce a nontraditional approach, the case-only design, which was originally proposed for assessing gene and disease associations, to detect gene-sex interaction in human longevity. Applications of this method to data collected from centenarian studies show that it can produce consistent results as compared with results obtained from case-control and other approaches. Important features of the application in human longevity studies are highlighted and discussed. Since centenarians constitute a special population representing successful ageing, the easily applicable case-only approach will be an important tool for screening potential major genes that contribute to human longevity. (AUTHORS)

    Download Info

    If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
    File URL: http://www.demogr.mpg.de/Papers/Working/wp-2001-012.pdf
    Download Restriction: no

    Bibliographic Info

    Paper provided by Max Planck Institute for Demographic Research, Rostock, Germany in its series MPIDR Working Papers with number WP-2001-012.

    as in new window
    Length:
    Date of creation: May 2001
    Date of revision:
    Handle: RePEc:dem:wpaper:wp-2001-012

    Contact details of provider:
    Web page: http://www.demogr.mpg.de/

    Related research

    Keywords:

    Find related papers by JEL classification:

    References

    No references listed on IDEAS
    You can help add them by filling out this form.

    Citations

    Lists

    This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.

    Statistics

    Access and download statistics

    Corrections

    When requesting a correction, please mention this item's handle: RePEc:dem:wpaper:wp-2001-012. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Peter Wilhelm).

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If references are entirely missing, you can add them using this form.

    If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.