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Meta-analytical Integration of Diagnostic Accuracy Studies in Stata

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  • Ben Dwamena

    (Division of Nuclear Medicine, Department of Radiology, University of Michigan Health System, Ann Arbor)

Abstract

This presentation will demonstrate how to perform diagnostic meta-analysis using midas , a user-written macro. midas is is comprehensive program of statistical and graphical routines for undertaking meta-analysis of diagnostic test performance in Stata. Primary data synthesis is performed within the bivariate generalized linear mixed modeling framework. Model specification, estimation and prediction are carried out with gllamm (Rabe-Hesketh et.al, spherical adaptive quadrature). Using the estimated coefficients and variance-covariance matrices, midas calculates the summary operating sensitivity and specificity (with confidence and prediction ellipses) in SROC space. Summary likelihood and odds ratios with relevant heterogeneity statistics are provided. midas facilitates extensive statistical and graphical data synthesis and exploratory analyses of unobserved heterogeneity, covariate effects, publication bias and subgroup analyses. Bayes' nomograms, likelihood ratio matrices and conditional probability plots may be obtained and used to guide clinical decision-making.

Suggested Citation

  • Ben Dwamena, 2007. "Meta-analytical Integration of Diagnostic Accuracy Studies in Stata," North American Stata Users' Group Meetings 2007 4, Stata Users Group, revised 05 Sep 2007.
    • Handle: RePEc:boc:asug07:4
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    File URL: http://repec.org/nasug2007/BD-nasug2007.ppt
    File Function: presentation slides
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    File URL: http://repec.org/nasug2007/midas.ado
    File Function: program code
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    File URL: http://repec.org/nasug2007/midas_examples9.ado
    File Function: sample job (version 9.x)
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    File URL: http://repec.org/nasug2007/midas_examples.ado
    File Function: sample job
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    File URL: http://repec.org/nasug2007/midas.hlp
    File Function: help file
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    File URL: http://repec.org/nasug2007/midas.sthlp
    File Function: help file
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    File URL: http://repec.org/nasug2007/midas_example_data.dta
    File Function: sample data file
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    Cited by:

    1. Helen L Storey & Ying Huang & Chris Crudder & Allison Golden & Tala de los Santos & Kenneth Hawkins, 2015. "A Meta-Analysis of Typhoid Diagnostic Accuracy Studies: A Recommendation to Adopt a Standardized Composite Reference," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-24, November.
    2. Jiayuan Wu & Liren Hu & Gaohua Zhang & Fenping Wu & Taiping He, 2015. "Accuracy of Presepsin in Sepsis Diagnosis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-15, July.
    3. Guocan Yu & Wuchen Zhao & Yanqin Shen & Pengfei Zhu & Hong Zheng, 2020. "Metagenomic next generation sequencing for the diagnosis of tuberculosis meningitis: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-12, December.

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