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Physiological and Immunological Activity

In: Understanding Fever and Body Temperature

Author

Listed:
  • Ewa Grodzinsky

    (Linköping University)

  • Märta Sund Levander

    (Linköping University)

Abstract

Half a century ago, immunology was almost synonymous with infectious diseases and microbiology. The immune system contains various immunological cells and neurotransmitters. These cells synthesize and secrete in response to foreign agents, stress, an autoimmune reaction, or mechanical injury. There are two different branches working together: the innate and the adaptive immune systems. An increase in body temperature has been known for a very long time to be associated with ‘something not is as it should be’. Cytokines are small functional proteins that play essential roles in shaping an immune response to foreign or self-antigens. Further, they induce an increase in body temperature and stimulate the synthesis of acute-phase proteins. Research on the pathogenesis of fever is today called ‘cytokine biology’, that is, pyrogenic activity.

Suggested Citation

  • Ewa Grodzinsky & Märta Sund Levander, 2020. "Physiological and Immunological Activity," Springer Books, in: Ewa Grodzinsky & Märta Sund Levander (ed.), Understanding Fever and Body Temperature, chapter 0, pages 67-96, Springer.
    • Handle: RePEc:spr:sprchp:978-3-030-21886-7_6
    DOI: 10.1007/978-3-030-21886-7_6
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