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A Practical Way to ISO/GUM Measurement Uncertainty for Analytical Assays Including In-House Validation Data

In: Quality Control in Laboratory

Author

Listed:
  • A. Gustavo Gonzalez
  • Mª Angeles Herrador
  • Agustin G. Asuero
  • Julia Martin

Abstract

In this contribution, we outline the estimation of measurement uncertainty of analytical assays in a practical way, according to the so-called reconciliation paradigm, by considering the heritance of uncertainties according to the ISO Guide to the expression of uncertainty in measurement (ISO/GUM) approach and the accuracy (bias and precision) study coming from the in-house method validation. A cause and effect analysis is performed by using the Ishikawa diagram or fishbone plot, consisting of a hierarchical structure reaching a final outcome that is the analytical result. The procedure is illustrated with a case study. This procedure may be very suitable for processing data in accreditation of routine assays.

Suggested Citation

  • A. Gustavo Gonzalez & Mª Angeles Herrador & Agustin G. Asuero & Julia Martin, 2018. "A Practical Way to ISO/GUM Measurement Uncertainty for Analytical Assays Including In-House Validation Data," Chapters, in: Gaffar Sarwar Zaman (ed.), Quality Control in Laboratory, IntechOpen.
    • Handle: RePEc:ito:pchaps:124082
    DOI: 10.5772/intechopen.72048
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    More about this item

    Keywords

    ISO/GUM approach; method validation; uncertainty measurement;
    All these keywords.

    JEL classification:

    • L15 - Industrial Organization - - Market Structure, Firm Strategy, and Market Performance - - - Information and Product Quality

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