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Population-level adult mortality following the expansion of antiretroviral therapy in Rakai, Uganda

Author

Listed:
  • Dorean Nabukalu
  • Georges Reniers
  • Kathryn A. Risher
  • Sylvia Blom
  • Emma Slaymaker
  • Chodziwadziwa Kabudula
  • Basia Zaba
  • Fred Nalugoda
  • Godfrey Kigozi
  • Fred Makumbi
  • David Serwadda
  • Steven J. Reynolds
  • Milly Marston
  • Jeffrey W. Eaton
  • Ron Gray
  • Maria Wawer
  • Nelson Sewankambo
  • Tom Lutalo

Abstract

There are limited data on the impact of antiretroviral therapy (ART) on population-level adult mortality in sub-Saharan Africa. We analysed data for 2000–14 from the Rakai Community Cohort Study (RCCS) in Uganda, where free ART was scaled up after 2004. Using non-parametric and parametric (Weibull) survival analysis, we estimated trends in average person-years lived between exact ages 15 and 50, per capita life-years lost to HIV, and the mortality hazards of people living with HIV (PLHIV). Between 2000 and 2014, average adult life-years lived before age 50 increased significantly, from 26.4 to 33.5 years for all women and from 28.6 to 33.8 years for all men. As of 2014, life-years lost to HIV had declined significantly, to 1.3 years among women and 0.4 years among men. Following the roll-out of ART, mortality reductions among PLHIV were initially larger in women than men, but this is no longer the case.

Suggested Citation

  • Dorean Nabukalu & Georges Reniers & Kathryn A. Risher & Sylvia Blom & Emma Slaymaker & Chodziwadziwa Kabudula & Basia Zaba & Fred Nalugoda & Godfrey Kigozi & Fred Makumbi & David Serwadda & Steven J. , 2020. "Population-level adult mortality following the expansion of antiretroviral therapy in Rakai, Uganda," Population Studies, Taylor & Francis Journals, vol. 74(1), pages 93-102, January.
  • Handle: RePEc:taf:rpstxx:v:74:y:2020:i:1:p:93-102
    DOI: 10.1080/00324728.2019.1595099
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