IDEAS home Printed from https://ideas.repec.org/a/taf/lstaxx/v52y2023i2p273-282.html
   My bibliography  Save this article

A testing procedure in clinical trials with multiple binary endpoints

Author

Listed:
  • Takuma Ishihara
  • Kouji Yamamoto

Abstract

The test treatment in confirmatory clinical trials is often assessed using multiple primary endpoints. We considered that trial efficacy is confirmed only when there is superiority of at least one endpoint and non-inferiority of the remaining endpoints. Some researchers proposed testing procedures for multiple primary endpoints that are continuous variables. However, there has not yet been discussion of the case in which a trial has multiple binary endpoints in the above framework. In this study, we consider a testing procedure for multiple primary endpoints that are binary, and evaluate the performance of the proposed method through simulations.

Suggested Citation

  • Takuma Ishihara & Kouji Yamamoto, 2023. "A testing procedure in clinical trials with multiple binary endpoints," Communications in Statistics - Theory and Methods, Taylor & Francis Journals, vol. 52(2), pages 273-282, January.
    • Handle: RePEc:taf:lstaxx:v:52:y:2023:i:2:p:273-282
    DOI: 10.1080/03610926.2021.1912766
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/03610926.2021.1912766
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/03610926.2021.1912766?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:lstaxx:v:52:y:2023:i:2:p:273-282. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/lsta .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.