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Kernel-Based Response-Adaptive Design for Continuous Responses

Author

Listed:
  • Uttam Bandyopadhyay
  • Atanu Biswas
  • Rahul Bhattacharya

Abstract

Response-adaptive designs are becoming popular in phase III clinical trials. We propose a response-adaptive design for a general class of continuous responses. The design is based on two kernels and does not require the existence of any moment of the response variables, and thus applicable for any type of continuous responses, even if the distribution is non-standard or the existence of moments of the response distribution is not guaranteed. Some possible properties of the design are discussed and are compared with some existing procedures. The methodology is illustrated by using some real life data.

Suggested Citation

  • Uttam Bandyopadhyay & Atanu Biswas & Rahul Bhattacharya, 2009. "Kernel-Based Response-Adaptive Design for Continuous Responses," Communications in Statistics - Theory and Methods, Taylor & Francis Journals, vol. 38(16-17), pages 2691-2705, October.
    • Handle: RePEc:taf:lstaxx:v:38:y:2009:i:16-17:p:2691-2705
    DOI: 10.1080/03610910902936216
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