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An analysis of the relationship between microneedle spacing, needle force and skin strain during the indentation phase prior to skin penetration

Author

Listed:
  • Matthew R. Potts
  • Sam L. Evans
  • Rhys Pullin
  • Sion A. Coulman
  • James C. Birchall
  • Hayley Wyatt

Abstract

Microneedle (MN) array patches present a promising new approach for the minimally invasive delivery of therapeutics and vaccines. However, ensuring reproducible insertion of MNs into the skin is challenging. The spacing and arrangement of MNs in an array are critical determinants of skin penetration and the mechanical integrity of the MNs. In this work, the finite element method was used to model the effect of MN spacing on needle reaction force and skin strain during the indentation phase prior to skin penetration. Spacings smaller than 2–3 mm (depending on variables, e.g., skin stretch) were found to significantly increase these parameters.

Suggested Citation

  • Matthew R. Potts & Sam L. Evans & Rhys Pullin & Sion A. Coulman & James C. Birchall & Hayley Wyatt, 2023. "An analysis of the relationship between microneedle spacing, needle force and skin strain during the indentation phase prior to skin penetration," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 26(14), pages 1719-1731, October.
    • Handle: RePEc:taf:gcmbxx:v:26:y:2023:i:14:p:1719-1731
    DOI: 10.1080/10255842.2022.2136486
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