IDEAS home Printed from https://ideas.repec.org/a/taf/gcmbxx/v26y2023i12p1419-1430.html
   My bibliography  Save this article

Multi-scale numerical simulation on mechano-transduction of osteocytes in different gravity fields

Author

Listed:
  • Chaohui Zhao
  • Haiying Liu
  • Congbiao Tian
  • Chunqiu Zhang
  • Wei Wang

Abstract

A three-dimensional model for osteocyte was established to research the mechanisms of mechano-transduction and amplification of primary cilium and osteocyte process in every gravity field. The results showed that significant stress concentration was observed in the area of physical connection between TES and the osteocyte process, where the fluid shear stress (FSS) was around two orders of magnitude higher than that in other areas. Due to the significant amplification effect of the TES structure on mechanical stimulation, making osteocyte process the “optimal mechanical receptor”. In microgravity, the mechanical signal conduction ability of the osteocyte decreased significantly.. HighlightsAt the micro-nano scale, a 3D model for single bone lacunae-osteocyte system is established.The stress amplification mechanism of the transverse element is verified.Compared with the primary cilium, osteocyte process is the ‘optimal mechanical receptor’.In microgravity, the mechanical signal conduction ability of osteocyte system decreased.

Suggested Citation

  • Chaohui Zhao & Haiying Liu & Congbiao Tian & Chunqiu Zhang & Wei Wang, 2023. "Multi-scale numerical simulation on mechano-transduction of osteocytes in different gravity fields," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 26(12), pages 1419-1430, September.
    • Handle: RePEc:taf:gcmbxx:v:26:y:2023:i:12:p:1419-1430
    DOI: 10.1080/10255842.2022.2117552
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/10255842.2022.2117552
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/10255842.2022.2117552?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:gcmbxx:v:26:y:2023:i:12:p:1419-1430. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/gcmb .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.