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A global sensitivity analysis approach applied to a multiscale model of microvascular flow

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  • L. Possenti
  • S. Di Gregorio
  • G. Casagrande
  • M. L. Costantino
  • T. Rancati
  • P. Zunino

Abstract

A global sensitivity analysis of a multiscale computational model of microvascular flow is presented. A total of 140 simulations have been completed and analyzed varying 6 input parameters and considering their effects on 7 output variables. Interestingly, the vascular network topology has been found as a determinant factor for both vasculature-related and interstitium-related quantities. Regarding the firsts, the vascular network topology has obtained a score of 5.5/6 and 6/6 for average and spatial distribution respectively (where 6 is the maximum and 1 is the minimum). On the other hand, considering interstitium-related quantities, the score is 4/6 and 5/6 for average and spatial distribution respectively. These results suggest that the network topology has a significant influence on the outcome of the computational analysis.

Suggested Citation

  • L. Possenti & S. Di Gregorio & G. Casagrande & M. L. Costantino & T. Rancati & P. Zunino, 2020. "A global sensitivity analysis approach applied to a multiscale model of microvascular flow," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 23(15), pages 1215-1224, November.
    • Handle: RePEc:taf:gcmbxx:v:23:y:2020:i:15:p:1215-1224
    DOI: 10.1080/10255842.2020.1793964
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