IDEAS home Printed from https://ideas.repec.org/a/taf/gcmbxx/v17y2014i1p11-30.html
   My bibliography  Save this article

Stress and strain localization in stretched collagenous tissues via a multiscale modelling approach

Author

Listed:
  • Michele Marino
  • Giuseppe Vairo

Abstract

Mechanobiology of cells in soft collagenous tissues is highly affected by both tissue response at the macroscale and stress/strain localization mechanisms due to features at lower scales. In this paper, the macroscale mechanical behaviour of soft collagenous tissues is modelled by a three-level multiscale approach, based on a multi-step homogenisation technique from nanoscale up to the macroscale. Nanoscale effects, related to both intermolecular cross-links and collagen mechanics, are accounted for, together with geometric nonlinearities at the microscale. Moreover, an effective submodelling procedure is conceived in order to evaluate the local stress and strain fields at the microscale, which is around and within cells. Numerical results, obtained by using an incremental finite element formulation and addressing stretched tendinous tissues, prove consistency and accuracy of the model at both macroscale and microscale, confirming also the effectiveness of the multiscale modelling concept for successfully analysing physiopathological processes in biological tissues.

Suggested Citation

  • Michele Marino & Giuseppe Vairo, 2014. "Stress and strain localization in stretched collagenous tissues via a multiscale modelling approach," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(1), pages 11-30, January.
  • Handle: RePEc:taf:gcmbxx:v:17:y:2014:i:1:p:11-30
    DOI: 10.1080/10255842.2012.658043
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/10255842.2012.658043
    Download Restriction: Access to full text is restricted to subscribers.

    File URL: https://libkey.io/10.1080/10255842.2012.658043?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:gcmbxx:v:17:y:2014:i:1:p:11-30. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/gcmb .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.