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Virtualisation of stress distribution in heart valve tissue

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  • Siyao Huang
  • Hsiao-Ying Shadow Huang

Abstract

This study presents an image-based finite element analysis incorporating histological photomicrographs of heart valve tissues. We report stress fields inside heart valve tissues, where heterogeneously distributed collagen fibres are responsible for transmitting forces into cells. Linear isotropic and anisotropic tissue material property models are incorporated to quantify the overall stress distributions in heart valve tissues. By establishing an effective predictive method with new computational tools and by performing virtual experiments on the heart valve tissue photomicrographs, we clarify how stresses are transferred from matrix to cell. The results clearly reveal the roles of heterogeneously distributed collagen fibres in mitigating stress developments inside heart valve tissues. Moreover, most local peak stresses occur around cell nuclei, suggesting that higher stress may be mediated by cells for biomechanical regulations.

Suggested Citation

  • Siyao Huang & Hsiao-Ying Shadow Huang, 2014. "Virtualisation of stress distribution in heart valve tissue," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(15), pages 1696-1704, November.
    • Handle: RePEc:taf:gcmbxx:v:17:y:2014:i:15:p:1696-1704
    DOI: 10.1080/10255842.2013.763937
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    References listed on IDEAS

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    1. T.M. Koch & B.D. Reddy & P. Zilla & T. Franz, 2010. "Aortic valve leaflet mechanical properties facilitate diastolic valve function," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 13(2), pages 225-234.
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