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Biomechanical evaluation of porous biodegradable scaffolds for revision knee arthroplasty

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  • Alexandre Terrier
  • Marjan Sedighi-Gilani
  • Alireza Roshan Ghias
  • Line Aschwanden
  • Dominique P. Pioletti

Abstract

Tibial bone defect is a critical problem for revision knee arthroplasty. Instead of using metallic spacer or cement, biodegradable scaffolds could be an alternative solution. A numerical model of a revision knee arthroplasty was thus developed to estimate the mechanical resistance of the scaffold in this demanding situation. The tibia, scaffold, and prosthesis were represented by simplified parameterised geometries. The maximal gait cycle force was applied asymmetrically to simulate a critical loading. Several parameters were analysed: 1) inter-individual variability, 2) cortical bone stiffness, 3) cortical bone thickness, 4) prosthesis fixation quality, and 5) scaffold thickness. The calculated scaffold strain was compared to its experimental ultimate strain. Among the tested parameters, failure was only predicted with scaffold thickness below 5 mm. This study suggests that biodegradable bone scaffolds could be used to fill bone defects in revision knee arthroplasty, but scaffold size seems to be the limiting factor.

Suggested Citation

  • Alexandre Terrier & Marjan Sedighi-Gilani & Alireza Roshan Ghias & Line Aschwanden & Dominique P. Pioletti, 2009. "Biomechanical evaluation of porous biodegradable scaffolds for revision knee arthroplasty," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 12(3), pages 333-339.
    • Handle: RePEc:taf:gcmbxx:v:12:y:2009:i:3:p:333-339
    DOI: 10.1080/10255840802603589
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    Cited by:

    1. A. Roshan-Ghias & A. Terrier & B.M. Jolles & D.P. Pioletti, 2014. "Translation of biomechanical concepts in bone tissue engineering: from animal study to revision knee arthroplasty," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(8), pages 845-852, June.
    2. Dominique P. Pioletti, 2010. "Biomechanics in bone tissue engineering," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 13(6), pages 837-846.
    3. Dominique P. Pioletti, 2013. "Integration of mechanotransduction concepts in bone tissue engineering," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 16(10), pages 1050-1055, October.

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