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Modelling drug elution from stents: effects of reversible binding in the vascular wall and degradable polymeric matrix

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  • A. Borghi
  • E. Foa
  • R. Balossino
  • F. Migliavacca
  • G. Dubini

Abstract

Today the most popular approach for the prevention of the restenosis consists in the use of the drug eluting stents. The stent acts as a source of drug, from a coating or from a reservoir, which is transported into and through the artery wall. In this study, the behaviour of a model of a hydrophilic drug (heparin) released from a coronary stent into the arterial wall is investigated. The presence of the specific binding site action is modelled using a reversible chemical reaction that explains the prolonged presence of drug in the vascular tissue. An axi-symmetric model of a single stent strut is considered. First an advection–diffusion problem is solved using the finite element method. Then a simplified model with diffusion only in the arterial wall is compared with: (i) a model including the presence of reversible binding sites in the vascular wall and (ii) a model featuring a drug reservoir made of a degradable polymeric matrix. The results show that the inclusion of a reversible binding for the drug leads to delayed release curves and that the polymer erosion affects the drug release showing a quicker elution of the drug from the stent.

Suggested Citation

  • A. Borghi & E. Foa & R. Balossino & F. Migliavacca & G. Dubini, 2008. "Modelling drug elution from stents: effects of reversible binding in the vascular wall and degradable polymeric matrix," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 11(4), pages 367-377.
    • Handle: RePEc:taf:gcmbxx:v:11:y:2008:i:4:p:367-377
    DOI: 10.1080/10255840801887555
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    Cited by:

    1. Mandal, Akash Pradip & Sarifuddin, & Mandal, Prashanta Kumar, 2015. "An unsteady analysis of arterial drug transport from half-embedded drug-eluting stent," Applied Mathematics and Computation, Elsevier, vol. 266(C), pages 968-981.

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