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Regression analysis of clustered failure time data with informative cluster size under the additive transformation models

Author

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  • Ling Chen

    (Washington University School of Medicine)

  • Yanqin Feng

    (Wuhan University
    Wuhan University)

  • Jianguo Sun

    (University of Missouri)

Abstract

This paper discusses regression analysis of clustered failure time data, which occur when the failure times of interest are collected from clusters. In particular, we consider the situation where the correlated failure times of interest may be related to cluster sizes. For inference, we present two estimation procedures, the weighted estimating equation-based method and the within-cluster resampling-based method, when the correlated failure times of interest arise from a class of additive transformation models. The former makes use of the inverse of cluster sizes as weights in the estimating equations, while the latter can be easily implemented by using the existing software packages for right-censored failure time data. An extensive simulation study is conducted and indicates that the proposed approaches work well in both the situations with and without informative cluster size. They are applied to a dental study that motivated this study.

Suggested Citation

  • Ling Chen & Yanqin Feng & Jianguo Sun, 2017. "Regression analysis of clustered failure time data with informative cluster size under the additive transformation models," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(4), pages 651-670, October.
    • Handle: RePEc:spr:lifeda:v:23:y:2017:i:4:d:10.1007_s10985-016-9384-x
    DOI: 10.1007/s10985-016-9384-x
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    References listed on IDEAS

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    1. Xiuyu J. Cong & Guosheng Yin & Yu Shen, 2007. "Marginal Analysis of Correlated Failure Time Data with Informative Cluster Sizes," Biometrics, The International Biometric Society, vol. 63(3), pages 663-672, September.
    2. David B. Dunson & Zhen Chen & Jean Harry, 2003. "A Bayesian Approach for Joint Modeling of Cluster Size and Subunit-Specific Outcomes," Biometrics, The International Biometric Society, vol. 59(3), pages 521-530, September.
    3. Guosheng Yin & Jianwen Cai, 2004. "Additive hazards model with multivariate failure time data," Biometrika, Biometrika Trust, vol. 91(4), pages 801-818, December.
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    Cited by:

    1. Zhongwen Zhang & Xiaoguang Wang & Yingwei Peng, 2022. "An additive hazards frailty model with semi-varying coefficients," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 28(1), pages 116-138, January.

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