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Methodology and results of real-world cost-effectiveness of carfilzomib in combination with lenalidomide and dexamethasone in relapsed multiple myeloma using registry data

Author

Listed:
  • M. Campioni

    (Economic Modeling Center of Excellence, Global Health Economics, Amgen (Europe) GmbH)

  • I. Agirrezabal

    (Economic Modeling Center of Excellence, Global Health Economics, Amgen (Europe) GmbH)

  • R. Hajek

    (University of Ostrava)

  • J. Minarik

    (Palacky University Olomouc)

  • L. Pour

    (University Hospital Brno and Faculty of Medicine Masaryk Universit)

  • I. Spicka

    (Charles University in Prague, First Faculty of Medicine and General Teaching Hospital)

  • S. Gonzalez-McQuire

    (Global Health Economics, Amgen (Europe) GmbH)

  • P. Jandova

    (Amgen s.r.o)

  • V. Maisnar

    (Charles University in Prague, First Faculty of Medicine and General Teaching Hospital)

Abstract

Objective To predict the real-world (RW) cost-effectiveness of carfilzomib in combination with lenalidomide and dexamethasone (KRd) versus lenalidomide and dexamethasone (Rd) in relapsed multiple myeloma (MM) patients after one to three prior therapies. Methods A partitioned survival model that included three health states (progression-free, progressed disease and death) was built. Progression-free survival (PFS), overall survival (OS) and time to discontinuation (TTD) data for the Rd arm were derived using the Registry of Monoclonal Gammopathies in the Czech Republic; the relative treatment effects of KRd versus Rd were estimated from the phase 3, randomised, ASPIRE trial, and were used to predict PFS, OS and TTD for KRd. The model was developed from the payer perspective and included drug costs, administration costs, monitoring costs, palliative care costs and adverse-event related costs collected from Czech sources. Results The base case incremental cost effectiveness ratio for KRd compared with Rd was €73,156 per quality-adjusted life year (QALY) gained. Patients on KRd incurred costs of €117,534 over their lifetime compared with €53,165 for patients on Rd. The QALYs gained were 2.63 and 1.75 for patients on KRd and Rd, respectively. Conclusions Combining the strengths of randomised controlled trials and observational databases in cost-effectiveness models can generate policy-relevant results to allow well-informed decision-making. The current model showed that KRd is likely to be cost-effective versus Rd in the RW and, therefore, the reimbursement of KRd represents an efficient allocation of resources within the healthcare system.

Suggested Citation

  • M. Campioni & I. Agirrezabal & R. Hajek & J. Minarik & L. Pour & I. Spicka & S. Gonzalez-McQuire & P. Jandova & V. Maisnar, 2020. "Methodology and results of real-world cost-effectiveness of carfilzomib in combination with lenalidomide and dexamethasone in relapsed multiple myeloma using registry data," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(2), pages 219-233, March.
    • Handle: RePEc:spr:eujhec:v:21:y:2020:i:2:d:10.1007_s10198-019-01122-6
    DOI: 10.1007/s10198-019-01122-6
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    References listed on IDEAS

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    1. Kelly Fust & Xiaoyan Li & Michael Maschio & Guillermo Villa & Anju Parthan & Richard Barron & Milton C. Weinstein & Luc Somers & Caroline Hoefkens & Gary H. Lyman, 2017. "Cost-Effectiveness Analysis of Prophylaxis Treatment Strategies to Reduce the Incidence of Febrile Neutropenia in Patients with Early-Stage Breast Cancer or Non-Hodgkin Lymphoma," PharmacoEconomics, Springer, vol. 35(4), pages 425-438, April.
    2. Chantal Gils & Saskia Groot & William Redekop & Miriam Koopman & Cornelis Punt & Carin Uyl-de Groot, 2013. "Real-World Cost-Effectiveness of Oxaliplatin in Stage III Colon Cancer: A Synthesis of Clinical Trial and Daily Practice Evidence," PharmacoEconomics, Springer, vol. 31(8), pages 703-718, August.
    3. Christopher Jackson & John Stevens & Shijie Ren & Nick Latimer & Laura Bojke & Andrea Manca & Linda Sharples, 2017. "Extrapolating Survival from Randomized Trials Using External Data: A Review of Methods," Medical Decision Making, , vol. 37(4), pages 377-390, May.
    4. Daniel Grima & Lisa Bernard & Elizabeth Dunn & Philip McFarlane & David Mendelssohn, 2012. "Cost-Effectiveness Analysis of Therapies for Chronic Kidney Disease Patients on Dialysis," PharmacoEconomics, Springer, vol. 30(11), pages 981-989, November.
    5. Neyt, Mattias & Cleemput, Irina & Thiry, Nancy & De Laet, Chris, 2012. "Calculating an intervention's (cost-)effectiveness for the real-world target population: The potential of combining strengths of both RCTs and observational data," Health Policy, Elsevier, vol. 106(2), pages 207-210.
    6. Patricia Guyot & Anthony E. Ades & Matthew Beasley & Béranger Lueza & Jean-Pierre Pignon & Nicky J. Welton, 2017. "Extrapolation of Survival Curves from Cancer Trials Using External Information," Medical Decision Making, , vol. 37(4), pages 353-366, May.
    7. Ruth Brown & Sean Stern & Sujith Dhanasiri & Steve Schey, 2013. "Lenalidomide for multiple myeloma: cost-effectiveness in patients with one prior therapy in England and Wales," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 14(3), pages 507-514, June.
    8. Richard Grieve & Neil Hawkins & Mark Pennington, 2013. "Extrapolation of Survival Data in Cost-effectiveness Analyses," Medical Decision Making, , vol. 33(6), pages 740-742, August.
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    More about this item

    Keywords

    Carfilzomib; Multiple myeloma; Cost-effectiveness; Real world; ASPIRE; Registry of Monoclonal Gammopathies;
    All these keywords.

    JEL classification:

    • I19 - Health, Education, and Welfare - - Health - - - Other

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