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Optimal Biopsy Protocols for Prostate Cancer

Author

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  • Ariela Sofer
  • Jianchao Zeng
  • Seong Mun

Abstract

Prostate cancer is the second leading cause of cancer-related death among American men. Biopsy for prostate cancer is a procedure known as transrectal ultrasound-guided needle biopsy. Because of the low resolution of ultrasound, the urologist cannot usually distinguish between cancerous and healthy tissue. For this reason, most biopsies follow standard protocols based on long-term experience of physicians. Recent studies indicate that these protocols have a significant rate of false negative diagnoses. In this research we use real prostate specimens removed by prostatectomy to develop a 3-D distribution map of cancer in the prostate, and use this to develop optimized biopsy procedures. The new procedures have detection rates that are significantly higher than those of current procedures, and thus have the potential to increase the rate of early detection of prostate cancer. Copyright Kluwer Academic Publishers 2003

Suggested Citation

  • Ariela Sofer & Jianchao Zeng & Seong Mun, 2003. "Optimal Biopsy Protocols for Prostate Cancer," Annals of Operations Research, Springer, vol. 119(1), pages 63-74, March.
    • Handle: RePEc:spr:annopr:v:119:y:2003:i:1:p:63-74:10.1023/a:1022974221137
    DOI: 10.1023/A:1022974221137
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    Cited by:

    1. Jingyu Zhang & Brian T. Denton & Hari Balasubramanian & Nilay D. Shah & Brant A. Inman, 2012. "Optimization of Prostate Biopsy Referral Decisions," Manufacturing & Service Operations Management, INFORMS, vol. 14(4), pages 529-547, October.

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