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Homozygous-Recessive Characteristics as a Biomarker of Predisposition for COVID-19

Author

Listed:
  • Darko GrujiÄ ić
  • Ljiljana Mirkov
  • Dragić Banković
  • Kristina Virijević
  • Dragoslav Marinković
  • Olivera MiloÅ¡ević-Djordjević

Abstract

Coronavirus disease (COVID-19), a new form of severe acute respiratory syndrome, has caused a global pandemic. The aim of this study was to analyze homozygous-recessive characteristics (HRC) in the group of COVID-19 patients, considering their gender, forms of the disease (mild and severe symptoms), risk factors: hypertension, diabetes mellitus type 2, hyperlipidemia, smoking habits, and the distribution of ABO blood group. Using the HRC test, we analyzed 20 HRCs in a sample of 321 individuals: 205 patients and 116 controls. The average HRC in patients was significantly higher than controls, as well as in patients with severe symptoms compared to patients with mild symptoms. The patients with higher HRC (cut-off ≤5.5) experienced a significantly increased risk of disease of 2.3 times ( OR  = 2.315, p  

Suggested Citation

  • Darko GrujiÄ ić & Ljiljana Mirkov & Dragić Banković & Kristina Virijević & Dragoslav Marinković & Olivera MiloÅ¡ević-Djordjević, 2023. "Homozygous-Recessive Characteristics as a Biomarker of Predisposition for COVID-19," Clinical Nursing Research, , vol. 32(3), pages 589-600, March.
  • Handle: RePEc:sae:clnure:v:32:y:2023:i:3:p:589-600
    DOI: 10.1177/10547738221147754
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