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Type 2 Diabetes Independent of Glycemic Control is Associated With Cognitive Impairments: Findings From NHANES

Author

Listed:
  • Rozmin Jiwani
  • Brittany Dennis
  • Alfonso L. Neri
  • Chandler Bess
  • Sara Espinoza
  • Jing Wang
  • Monica C. Serra

Abstract

Examine the association between glycemic control and cognition. Included subjects ≥60 years who participated in the 2013 to 2014 National Health and Nutrition Examination Survey and completed one of the followings: Consortium to Establish a Registry for Alzheimer’s Disease Word List (CERAD-WL), Animal Fluency (AF), Digit Symbol Substitution Test (DSST), and CERAD-Delayed Recall (CERAD-DR). Stratified participants into: No type 2 diabetes (T2D; N  = 557), Controlled T2D ( N  = 41), Uncontrolled T2D ( N  = 120), and Untreated T2D ( N  = 86). Multiple regression was used to examine the association between variables. After adjusting for demographics and cardiovascular risk factors, Uncontrolled T2D was associated with lower DSST (β = −3.164, p  = .04), and Untreated T2D was associated with a trend for having lower CERAD-DR (β = −.496, p  = .06) scores. T2D, independent of glycemic control, is associated with cognitive impairment and this relationship is influenced by modifiable and non-modifiable risk factors.

Suggested Citation

  • Rozmin Jiwani & Brittany Dennis & Alfonso L. Neri & Chandler Bess & Sara Espinoza & Jing Wang & Monica C. Serra, 2022. "Type 2 Diabetes Independent of Glycemic Control is Associated With Cognitive Impairments: Findings From NHANES," Clinical Nursing Research, , vol. 31(7), pages 1225-1233, September.
    • Handle: RePEc:sae:clnure:v:31:y:2022:i:7:p:1225-1233
    DOI: 10.1177/10547738221100344
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