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Nonsterile immunity to cryptosporidiosis in infants is associated with mucosal IgA against the sporozoite and protection from malnutrition

Author

Listed:
  • Mamun Kabir
  • Masud Alam
  • Uma Nayak
  • Tuhinur Arju
  • Biplob Hossain
  • Rubaiya Tarannum
  • Amena Khatun
  • Jennifer A White
  • Jennie Z Ma
  • Rashidul Haque
  • William A Petri Jr
  • Carol A Gilchrist

Abstract

We conducted a longitudinal study of cryptosporidiosis from birth to three years of age in an urban slum of Dhaka Bangladesh. Fecal DNA was extracted from monthly surveillance samples and diarrheal stool samples collected from 392 infants from birth to three years. A pan-Cryptosporidium qPCR assay was used to identify sub-clinical and symptomatic cryptosporidiosis. Anthropometric measurements were collected quarterly to assess child nutritional status. 31% (121/392) of children experienced a single and 57% (222/392) multiple infections with Cryptosporidium. Repeat infections had a lower burden of parasites in the stool (Cq slope = -1.85; p

Suggested Citation

  • Mamun Kabir & Masud Alam & Uma Nayak & Tuhinur Arju & Biplob Hossain & Rubaiya Tarannum & Amena Khatun & Jennifer A White & Jennie Z Ma & Rashidul Haque & William A Petri Jr & Carol A Gilchrist, 2021. "Nonsterile immunity to cryptosporidiosis in infants is associated with mucosal IgA against the sporozoite and protection from malnutrition," PLOS Pathogens, Public Library of Science, vol. 17(6), pages 1-18, June.
    • Handle: RePEc:plo:ppat00:1009445
    DOI: 10.1371/journal.ppat.1009445
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