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A molecular insight into the lipid changes of pig Longissimus thoracis muscle following dietary supplementation with functional ingredients

Author

Listed:
  • Gabriele Rocchetti
  • Marika Vitali
  • Martina Zappaterra
  • Laura Righetti
  • Rubina Sirri
  • Luigi Lucini
  • Chiara Dall’Asta
  • Roberta Davoli
  • Gianni Galaverna

Abstract

In this work, the Longissimus thoracis pig skeletal muscle was used as a model to investigate the impact of two different diets, supplemented with n-3 polyunsaturated fatty acids from extruded linseed (L) and polyphenols from grape skin and oregano extracts (L+P), on the lipidomic profile of meat. A standard diet for growing-finishing pigs (CTRL) was used as a control. Changes in lipids profile were investigated through an untargeted lipidomics and transcriptomics combined investigation. The lipidomics identified 1507 compounds, with 195 compounds fitting with the MS/MS spectra of LipidBlast database. When compared with the CTRL group, the L+P diet significantly increased 15 glycerophospholipids and 8 sphingolipids, while the L diet determined a marked up-accumulation of glycerolipids. According to the correlations outlined between discriminant lipids and genes, the L diet may act preventing adipogenesis and the related inflammation processes, while the L+P diet promoted the expression of genes involved in lipids’ biosynthesis and adipogenic extracellular matrix formation and functioning.

Suggested Citation

  • Gabriele Rocchetti & Marika Vitali & Martina Zappaterra & Laura Righetti & Rubina Sirri & Luigi Lucini & Chiara Dall’Asta & Roberta Davoli & Gianni Galaverna, 2022. "A molecular insight into the lipid changes of pig Longissimus thoracis muscle following dietary supplementation with functional ingredients," PLOS ONE, Public Library of Science, vol. 17(3), pages 1-24, March.
    • Handle: RePEc:plo:pone00:0264953
    DOI: 10.1371/journal.pone.0264953
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    References listed on IDEAS

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    1. Kandice R. Levental & Eric Malmberg & Jessica L. Symons & Yang-Yi Fan & Robert S. Chapkin & Robert Ernst & Ilya Levental, 2020. "Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    2. O'Sullivan, T.A. & Hafekost, K. & Mitrou, F. & Lawrence, D., 2013. "Food sources of saturated fat and the association with mortality: A meta-analysis," American Journal of Public Health, American Public Health Association, vol. 103(9), pages 31-42.
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