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Effects of tocotrienols supplementation on markers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials

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  • Ban-Hock Khor
  • Hui-Ci Tiong
  • Shing Cheng Tan
  • Sok Kuan Wong
  • Kok-Yong Chin
  • Tilakavati Karupaiah
  • Soelaiman Ima-Nirwana
  • Abdul Halim Abdul Gafor

Abstract

Studies investigating the effects of tocotrienols on inflammation and oxidative stress have yielded inconsistent results. This systematic review and meta-analysis aimed to evaluate the effects of tocotrienols supplementation on inflammatory and oxidative stress biomarkers. We searched PubMed, Scopus, and Cochrane Central Register of Controlled Trials from inception until 13 July 2020 to identify randomized controlled trials supplementing tocotrienols and reporting circulating inflammatory or oxidative stress outcomes. Weighted mean difference (WMD) and corresponding 95% confidence interval (CI) were determined by pooling eligible studies. Nineteen studies were included for qualitative analysis, and 13 studies were included for the meta-analyses. A significant reduction in C-reactive protein levels (WMD: −0.52 mg/L, 95% CI: −0.73, −0.32, p

Suggested Citation

  • Ban-Hock Khor & Hui-Ci Tiong & Shing Cheng Tan & Sok Kuan Wong & Kok-Yong Chin & Tilakavati Karupaiah & Soelaiman Ima-Nirwana & Abdul Halim Abdul Gafor, 2021. "Effects of tocotrienols supplementation on markers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 16(7), pages 1-20, July.
    • Handle: RePEc:plo:pone00:0255205
    DOI: 10.1371/journal.pone.0255205
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    1. Ruslan Medzhitov, 2008. "Origin and physiological roles of inflammation," Nature, Nature, vol. 454(7203), pages 428-435, July.
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