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Efficacy of Banxia Xiexin decoction for chronic atrophic gastritis: A systematic review and meta-analysis

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  • Yang Cao
  • Yixin Zheng
  • Jingbin Niu
  • Chunmei Zhu
  • Decai Yang
  • Fen Rong
  • Guoping Liu

Abstract

Background: Banxia Xiexin decoction (BXD), a classical formula of traditional Chinese medicine (TCM), has been wildly used for chronic atrophic gastritis (CAG) patients with the cold-heat complex syndrome in China, and achieved satisfied effects. However, the clinical effects of it remains unclear. Purpose: The purpose of this article is to evaluate the clinical efficacy and safety of BXD for CAG treatment. Methods: We searched seven electronic databases including Ovid, Embase, PubMed, Cochrane Library, Wan-fang database, VIP (Chinese Scientific Journals Database) and CNKI (China National Knowledge Infrastructure) from their inception to September 21, 2020. We used Jadad scale and Cochrane Collaboration’s risk of bias tool to make evaluation of methodological quality. Revman 5.3 statistical software was used for statistical processing to evaluate the clinical efficacy and safety of BXD. Results: 26 randomized controlled trials (RCTs) totaling 1985 patients were identified for analysis. Meta-analysis showed that BXD treatment was more effective (RR 1.29; 95%CI 1.24, 1.35; P

Suggested Citation

  • Yang Cao & Yixin Zheng & Jingbin Niu & Chunmei Zhu & Decai Yang & Fen Rong & Guoping Liu, 2020. "Efficacy of Banxia Xiexin decoction for chronic atrophic gastritis: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-18, October.
    • Handle: RePEc:plo:pone00:0241202
    DOI: 10.1371/journal.pone.0241202
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    References listed on IDEAS

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    1. Yun-kai Dai & Yun-zhan Zhang & Dan-yan Li & Jin-tong Ye & Ling-feng Zeng & Qi Wang & Ling Hu, 2017. "The efficacy of Jianpi Yiqi therapy for chronic atrophic gastritis: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-21, July.
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