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Bright light therapy in the treatment of patients with bipolar disorder: A systematic review and meta-analysis

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  • Shengjun Wang
  • Zhigang Zhang
  • Li Yao
  • Nannan Ding
  • Lingjie Jiang
  • Yuchen Wu

Abstract

The treatment of depressive symptoms of bipolar disorder (BD) has received increasing attention. Recently, some studies have shown that bright light therapy (BLT) seems to be useful for BD depression. This meta-analysis is intended to further elucidate the role of BLT in depressive symptoms in patients with BD. Register of Systematic Reviews PROSPERO: CRD 420191 33642.Randomized controlled trials and cohort studies were retrieved in PubMed, Cochrane Library, EMbase, Web of Science, CINHAL, CBM, CNKI, VIP, and Wanfang from their foundation to March 2020, and other sources as supplement was also retrieved. Data were extracted after strict evaluation of literature quality by two researchers, and Meta-analysis was conducted on literatures that met the inclusion criteria. Meta-analysis was performed using Revman 5.3 software. In total, 12 studies including 847 patients with BD depression were included in our meta-analysis. A meta-analysis found significant differences between BLT and placebo for the following outcomes: (1) depression severity before and after BLT [SMD = -0.43, 95% CI (-0.73,-0.13), P

Suggested Citation

  • Shengjun Wang & Zhigang Zhang & Li Yao & Nannan Ding & Lingjie Jiang & Yuchen Wu, 2020. "Bright light therapy in the treatment of patients with bipolar disorder: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-19, May.
    • Handle: RePEc:plo:pone00:0232798
    DOI: 10.1371/journal.pone.0232798
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    1. Eva Hernandez-Garcia & Evangelia Chrysikou & Anastasia Z. Kalea, 2021. "The Interplay between Housing Environmental Attributes and Design Exposures and Psychoneuroimmunology Profile—An Exploratory Review and Analysis Paper in the Cancer Survivors’ Mental Health Morbidity ," IJERPH, MDPI, vol. 18(20), pages 1-32, October.

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