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Impact of systemic treatments on the course of HLA-B27-associated uveitis: A retrospective study of 101 patients

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Listed:
  • Nabil Bouzid
  • Yvan Jamilloux
  • Roland Chapurlat
  • Pierre Pradat
  • Audrey De Parisot
  • Laurent Kodjikian
  • Pascal Sève

Abstract

Purpose: To investigate the efficacy and tolerance of systemic treatments for the prevention of HLA-B27-associated acute uveitis (AU) recurrence. Methods: Retrospective review of patients with HLA-B27-associated uveitis followed in our tertiary center over a 15-year period. Systemic treatments were prescribed to patients with frequent (more than 2 flares per year) or severe uveitis, according to a step-up strategy Results: 101 patients (51.5% of men, 88.1% of white Europeans) with a median age of 37 years. AU was mostly recurrent (68.3%) and associated with spondyloarthritis (60.4%). After a median follow-up duration of 22 months (3–73), 37.6% of the patients have received systemic treatment. 88.5% of the patients have been treated with sulfasalazine (SSZ) for ophthalmologic purposes (23/26). Methotrexate (MTX) and anti-TNFα agents have been initiated for a rheumatologic indication in 81.8% (9/11) and 100% of the patients (13/13), respectively. The annual uveitis relapse rate significantly decreased on SSZ (0.37 recurrences/year versus baseline 2.46 recurrences/year; p

Suggested Citation

  • Nabil Bouzid & Yvan Jamilloux & Roland Chapurlat & Pierre Pradat & Audrey De Parisot & Laurent Kodjikian & Pascal Sève, 2020. "Impact of systemic treatments on the course of HLA-B27-associated uveitis: A retrospective study of 101 patients," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-12, March.
    • Handle: RePEc:plo:pone00:0230560
    DOI: 10.1371/journal.pone.0230560
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