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Bone mineral density changes among people living with HIV who have started with TDF-containing regimen: A five-year prospective study

Author

Listed:
  • Win Min Han
  • Lalita Wattanachanya
  • Tanakorn Apornpong
  • Jureeporn Jantrapakde
  • Anchalee Avihingsanon
  • Stephen J Kerr
  • Nipat Teeratakulpisarn
  • Tanate Jadwattanakul
  • Tawatchai Chaiwatanarat
  • Patinut Buranasupkajorn
  • Reshmie Ramautarsing
  • Nittaya Phanuphak
  • Sarat Sunthornyothin
  • Kiat Ruxrungtham
  • Praphan Phanuphak
  • TNT 003.1 study team

Abstract

There are limited data regarding long-term BMD changes over time among treatment-naïve people living with HIV (PLHIV) after initiating combined antiretroviral therapy (cART) in Asia. We aimed to study bone mineral density (BMD) changes among treatment-naïve PLHIV started treatment with tenofovir disoproxil fumarate (TDF)- or non-TDF-containing regimen and HIV-uninfected controls in an Asian setting. The study was a five-year prospective study. BMD at lumbar spine (LS) (L1 to L4), total hip (TH), and femoral neck (FN) were measured by dual energy X-ray absorptiometry (DEXA) scans at baseline, months 12, 24 and 60. Multivariate logistic regression models were used to explore factors associated with mean BMD ≥5% reduction after 5 years of cART. A total of 106 PLHIV (75 and 31 started TDF- and non-TDF-containing regimen, respectively) and 66 HIV-uninfected individuals were enrolled. The mean percent changes of BMD were significantly different longitudinally between TDF and non-TDF users (p

Suggested Citation

  • Win Min Han & Lalita Wattanachanya & Tanakorn Apornpong & Jureeporn Jantrapakde & Anchalee Avihingsanon & Stephen J Kerr & Nipat Teeratakulpisarn & Tanate Jadwattanakul & Tawatchai Chaiwatanarat & Pat, 2020. "Bone mineral density changes among people living with HIV who have started with TDF-containing regimen: A five-year prospective study," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-14, March.
    • Handle: RePEc:plo:pone00:0230368
    DOI: 10.1371/journal.pone.0230368
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