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Methylation of SRD5A2 promoter predicts a better outcome for castration-resistant prostate cancer patients undergoing androgen deprivation therapy

Author

Listed:
  • Zongwei Wang
  • Tuo Deng
  • Xingbo Long
  • Xueming Lin
  • Shulin Wu
  • Hongbo Wang
  • Rongbin Ge
  • Zhenwei Zhang
  • Chin-Lee Wu
  • Mary-Ellen Taplin
  • Aria F Olumi

Abstract

Purpose: To determine whether SRD5A2 promoter methylation is associated with cancer progression during androgen deprivation therapy (ADT) in CRPC. Patients and methods: In a Local CRPC cohort, 42 prostatic specimens were collected from patients who were diagnosed as CRPC and underwent transurethral resection of the prostate (TURP) at Massachusetts General Hospital (MGH). In a metastatic CRPC (Met CRPC) cohort, 12 metastatic biopsies were collected from CRPC patients who would be treated with abiraterone plus dutasteride (Clinical Trial NCT01393730). As controls, 36 benign prostatic specimens were collected from patients undergoing prostate reduction surgery for symptoms of bladder outlet obstruction secondary to benign prostatic hyperplasia (BPH). The methylation status of cytosine-phosphate-guanine (CpG) site(s) at SRD5A2 promoter regions was tested. Results: Compared with benign prostatic tissue, CRPC samples demonstrated higher SRD5A2 methylation in the whole promoter region (Local CRPC cohort: P

Suggested Citation

  • Zongwei Wang & Tuo Deng & Xingbo Long & Xueming Lin & Shulin Wu & Hongbo Wang & Rongbin Ge & Zhenwei Zhang & Chin-Lee Wu & Mary-Ellen Taplin & Aria F Olumi, 2020. "Methylation of SRD5A2 promoter predicts a better outcome for castration-resistant prostate cancer patients undergoing androgen deprivation therapy," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-15, March.
    • Handle: RePEc:plo:pone00:0229754
    DOI: 10.1371/journal.pone.0229754
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