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Association between TSH levels within the reference range and adiposity markers at the baseline of the ELSA–Brasil study

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  • Maria de Fátima Haueisen Sander Diniz
  • Alline Maria Rezende Beleigoli
  • Isabela M Benseñor
  • Paulo A Lotufo
  • Alessandra C Goulart
  • Sandhi Maria Barreto

Abstract

Background: The association of thyrotropin (TSH) with overall (body mass index, BMI), visceral (waist circumference and steatosis), and upper subcutaneous (neck circumference, NC) adiposity markers is still controversial, and the aim of this study is to assess these associations in the baseline data of a large cohort from ELSA-Brasil. Methods and findings: This cross-sectional study included 11,224 participants with normal thyroid function (normal TSH levels). BMI, waist circumference, NC and steatosis, defined by hepatic attenuation (mild or moderate/severe) were the explicative variables. TSH levels were log transformed (logTSH), and multivariate linear regression models were generated to estimate the associations between logTSH and BMI (continuous and categorized), waist circumference, NC, and steatosis after adjusting for sociodemographic characteristics, health behaviors, and comorbidities. The mean age was 51.5±8.9 years, 5,793 (51.6%) participants were women, 21.8% (n = 2,444) were obese, and 15.1% of the sample was TPOAb positive. The TSH levels were significantly higher in the obese group than in the reference group (

Suggested Citation

  • Maria de Fátima Haueisen Sander Diniz & Alline Maria Rezende Beleigoli & Isabela M Benseñor & Paulo A Lotufo & Alessandra C Goulart & Sandhi Maria Barreto, 2020. "Association between TSH levels within the reference range and adiposity markers at the baseline of the ELSA–Brasil study," PLOS ONE, Public Library of Science, vol. 15(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0228801
    DOI: 10.1371/journal.pone.0228801
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