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Comparative studies of two generations of NanoString nCounter System

Author

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  • Lianbo Yu
  • Sagar Bhayana
  • Naduparambil K Jacob
  • Paolo Fadda

Abstract

The NanoString nCounter System has been widely used in basic science and translational science research for the past decade. The System consists of two instruments: the PrepStation and the Digital Analyzer, and both have been continuously improved with evolving technologies. A great amount of research data have been generated at multiple research laboratories with the employment of different generations of the System. With the need of integrating multiple datasets, researchers are interested to know whether signals are comparable between different generations of the System. Toward this end, we designed a profiling study to compare performance of two generations of the NanoString nCounter System using a common set of biological samples. Using graphical tools and statistical models, we found that two different generations of NanoString nCounter System produced equivalent signals and signal deviations are in the range of random background noises for the medium-high expression levels.

Suggested Citation

  • Lianbo Yu & Sagar Bhayana & Naduparambil K Jacob & Paolo Fadda, 2019. "Comparative studies of two generations of NanoString nCounter System," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-12, November.
    • Handle: RePEc:plo:pone00:0225505
    DOI: 10.1371/journal.pone.0225505
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