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Estimating genome-wide off-target effects for pyrrole-imidazole polyamide binding by a pathway-based expression profiling approach

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Listed:
  • Jason Lin
  • Sakthisri Krishnamurthy
  • Hiroyuki Yoda
  • Yoshinao Shinozaki
  • Takayoshi Watanabe
  • Nobuko Koshikawa
  • Atsushi Takatori
  • Paul Horton
  • Hiroki Nagase

Abstract

In the search for new pharmaceutical leads, especially with DNA-binding molecules or genome editing methods, the issue of side and off-target effects have always been thorny in nature. A particular case is the investigation into the off-target effects of N-methylpyrrole-N-methylimidazole polyamides, a naturally inspired class of DNA binders with strong affinity to the minor-groove and sequence specificity, but at

Suggested Citation

  • Jason Lin & Sakthisri Krishnamurthy & Hiroyuki Yoda & Yoshinao Shinozaki & Takayoshi Watanabe & Nobuko Koshikawa & Atsushi Takatori & Paul Horton & Hiroki Nagase, 2019. "Estimating genome-wide off-target effects for pyrrole-imidazole polyamide binding by a pathway-based expression profiling approach," PLOS ONE, Public Library of Science, vol. 14(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0215247
    DOI: 10.1371/journal.pone.0215247
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    References listed on IDEAS

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    1. Heidi Ledford, 2015. "Cancer: The Ras renaissance," Nature, Nature, vol. 520(7547), pages 278-280, April.
    2. Kiriko Hiraoka & Takahiro Inoue & Rhys Dylan Taylor & Takayoshi Watanabe & Nobuko Koshikawa & Hiroyuki Yoda & Ken-ichi Shinohara & Atsushi Takatori & Hirokazu Sugimoto & Yoshiaki Maru & Tadamichi Dend, 2015. "Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole–imidazole polyamide conjugate," Nature Communications, Nature, vol. 6(1), pages 1-8, November.
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