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Premedication practices for delivery room intubations in premature infants in France: Results from the EPIPAGE 2 cohort study

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Listed:
  • Elizabeth Walter-Nicolet
  • Emilie Courtois
  • Christophe Milesi
  • Pierre-Yves Ancel
  • Alain Beuchée
  • Pierre Tourneux
  • Valérie Benhammou
  • Ricardo Carbajal
  • Xavier Durrmeyer

Abstract

Objectives: To assess premedication practices before tracheal intubation of premature newborns in the delivery room (DR). Study design: From the national population-based prospective EPIPAGE 2 cohort in 2011, we extracted all live born preterms intubated in the DR in level-3 centers, without subsequent circulatory resuscitation. Studied outcomes included the rate and type of premedication, infants’ and maternities’ characteristics and survival and major neonatal morbidities at discharge from hospital. Univariate and multivariate analysis were performed and a generalized estimating equation was used to identify factors associated with premedication use. Results: Out of 1494 included neonates born in 65 maternities, 76 (5.1%) received a premedication. Midazolam was the most used drug accounting for 49% of the nine drugs regimens observed. Premedicated, as compared to non premedicated neonates, had a higher median [IQR] gestational age (30 [28–31] vs 28 [27–30] weeks, p

Suggested Citation

  • Elizabeth Walter-Nicolet & Emilie Courtois & Christophe Milesi & Pierre-Yves Ancel & Alain Beuchée & Pierre Tourneux & Valérie Benhammou & Ricardo Carbajal & Xavier Durrmeyer, 2019. "Premedication practices for delivery room intubations in premature infants in France: Results from the EPIPAGE 2 cohort study," PLOS ONE, Public Library of Science, vol. 14(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0215150
    DOI: 10.1371/journal.pone.0215150
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