IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0213658.html
   My bibliography  Save this article

Mean platelet volume is more important than age for defining reference intervals of platelet counts

Author

Listed:
  • Till Ittermann
  • Martin A Feig
  • Astrid Petersmann
  • Dörte Radke
  • Andreas Greinacher
  • Henry Völzke
  • Thomas Thiele

Abstract

Background: Platelet count is known to be associated with sex, age and mean platelet volume (MPV). Sex and age were proposed for adjustment of platelet count reference intervals, but MPV is currently not used for further adjustment. We investigated the association of MPV, age and sex with platelet counts and established individualized reference ranges respecting MPV. Methods: The association of platelet count with age, sex and MPV was assessed in healthy participants (n = 3,033 individuals; 1,542 women) in the cross-sectional population-based cohort Study of Health in Pomerania. Reference intervals respecting age, sex, and MPV were estimated using quantile regressions for the 2.5th and 97.5th percentile. Results: Women had higher platelet counts than men (239 vs. 207 x109/L, p

Suggested Citation

  • Till Ittermann & Martin A Feig & Astrid Petersmann & Dörte Radke & Andreas Greinacher & Henry Völzke & Thomas Thiele, 2019. "Mean platelet volume is more important than age for defining reference intervals of platelet counts," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0213658
    DOI: 10.1371/journal.pone.0213658
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213658
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0213658&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0213658?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0213658. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.