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Molecular characterization of low grade and high grade bladder cancer

Author

Listed:
  • Alessandro Apollo
  • Valerio Ortenzi
  • Cristian Scatena
  • Katia Zavaglia
  • Paolo Aretini
  • Francesca Lessi
  • Sara Franceschi
  • Sara Tomei
  • Carlo Alberto Sepich
  • Paolo Viacava
  • Chiara Maria Mazzanti
  • Antonio Giuseppe Naccarato

Abstract

Background: Bladder cancer (BC) is the 9th most common cancer diagnosis worldwide. Low grade (LG) represents 70% of all BCs, characterized by recurrence and rare ability (10–15%) to progress to high grade (HG) and invade. The remaining 30% is high grade (HG), fast invasive BC, which is resistant to therapy. Identifying biomarkers for predicting those tumors able to progress is a key goal for patient outcome improvement. This study focuses on the most promising prognostic markers. Materials and methods: TP53 and FGFR3 mutational status, Survivin, CK19, CK20, E-cadherin and CD44 gene expression analysis were performed on 66 BCs. Results: Survivin was found associated to tumor grade (p

Suggested Citation

  • Alessandro Apollo & Valerio Ortenzi & Cristian Scatena & Katia Zavaglia & Paolo Aretini & Francesca Lessi & Sara Franceschi & Sara Tomei & Carlo Alberto Sepich & Paolo Viacava & Chiara Maria Mazzanti , 2019. "Molecular characterization of low grade and high grade bladder cancer," PLOS ONE, Public Library of Science, vol. 14(1), pages 1-17, January.
    • Handle: RePEc:plo:pone00:0210635
    DOI: 10.1371/journal.pone.0210635
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