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Cervico-vaginal inflammatory cytokine alterations after intrauterine contraceptive device insertion: A pilot study

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  • Priya Sharma
  • Kamnoosh Shahabi
  • Rachel Spitzer
  • Michele Farrugia
  • Rupert Kaul
  • Mark Yudin

Abstract

In a prospective study of twenty sexually transmitted infection (STI)-free women, we examined the impact of an intrauterine contraceptive device (IUCD) insertion on cervico-vaginal cytokine levels. Nine women chose the levonorgestrel-containing IUCD and eight chose a copper IUCD. A cervico-vaginal swab was collected for cytokine analysis pre-insertion and four weeks post-insertion. Significant increases were noted in levels of IL-1α (median 483.4 versus 316.6 pg/mL, p = 0.046), IL-1β (median 605.7 versus 147.3 pg/mL, p = 0.018), IL-6 (median 570.1 versus 157.3 pg/mL, p = 0.046), TNFα (median 1.19 versus 0.6 pg/mL, p = 0.029) and the chemokine MCP-1 (median 340.2 versus 135.2 pg/mL, p = 0.003). No significant changes were noted in the levels of GM-CSF, IL-8, MIG, MIP-3α, RANTES, IL-10, IL-17, IP-10, MIP-1β. Whether this increase in pro-inflammatory cytokine levels decreases epithelial barrier integrity and enhances susceptibility to STIs, including HIV, merits further study.

Suggested Citation

  • Priya Sharma & Kamnoosh Shahabi & Rachel Spitzer & Michele Farrugia & Rupert Kaul & Mark Yudin, 2018. "Cervico-vaginal inflammatory cytokine alterations after intrauterine contraceptive device insertion: A pilot study," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-7, December.
    • Handle: RePEc:plo:pone00:0207266
    DOI: 10.1371/journal.pone.0207266
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