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Circulating levels of sclerostin are associated with cardiovascular mortality

Author

Listed:
  • Cristina Novo-Rodríguez
  • Beatriz García-Fontana
  • Juan De Dios Luna-Del Castillo
  • Francisco Andújar-Vera
  • Verónica Ávila-Rubio
  • Cristina García-Fontana
  • Sonia Morales-Santana
  • Pedro Rozas-Moreno
  • Manuel Muñoz-Torres

Abstract

Cardiovascular diseases are a health problem throughout the world, especially in people with diabetes. The identification of cardiovascular disease biomarkers can improve risk stratification. Sclerostin is a modulator of the Wnt/β-catenin signalling pathway in different tissues, and it has recently been linked to vascular biology. The current study aimed to evaluate the relationship between circulating sclerostin levels and cardiovascular and non-cardiovascular mortality in individuals with and without type 2 diabetes. We followed up a cohort of 130 participants (mean age 56.8 years; 48.5% females; 75 with type 2 diabetes; 46 with prevalent cardiovascular disease) in which serum sclerostin levels were measured at the baseline. Time to death (both of cardiovascular and non-cardiovascular causes) was assessed to establish the relationship between sclerostin and mortality. We found that serum sclerostin concentrations were significantly higher in patients with prevalent cardiovascular disease (p

Suggested Citation

  • Cristina Novo-Rodríguez & Beatriz García-Fontana & Juan De Dios Luna-Del Castillo & Francisco Andújar-Vera & Verónica Ávila-Rubio & Cristina García-Fontana & Sonia Morales-Santana & Pedro Rozas-Moreno, 2018. "Circulating levels of sclerostin are associated with cardiovascular mortality," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-14, June.
    • Handle: RePEc:plo:pone00:0199504
    DOI: 10.1371/journal.pone.0199504
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    Cited by:

    1. Raquel Sanabria-de la Torre & Sheila González-Salvatierra & Cristina García-Fontana & Francisco Andújar-Vera & Beatriz García-Fontana & Manuel Muñoz-Torres & Blanca Riquelme-Gallego, 2022. "Exploring the Role of Sclerostin as a Biomarker of Cardiovascular Disease and Mortality: A Scoping Review," IJERPH, MDPI, vol. 19(23), pages 1-14, November.

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