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The efficacy of chimeric antigen receptor (CAR) immunotherapy in animal models for solid tumors: A systematic review and meta-analysis

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  • Yingcheng Wu
  • Ran Xu
  • Keren Jia
  • Hui Shi

Abstract

Background: Most recently, an emerging theme in the field of tumor immunology predominates: chimeric antigen receptor (CAR) therapy in treating solid tumors. The number of related preclinical trials was surging. However, an evaluation of the effects of preclinical studies remained absent. Hence, a meta-analysis was conducted on the efficacy of CAR in animal models for solid tumors. Methods: The authors searched PubMed/Medline, Embase, and Google scholar up to April 2017. HR for survival was extracted based on the survival curve. The authors used fixed effect models to combine the results of all the trials. Heterogeneity was assessed by I-square statistic. Quality assessment was conducted following the Stroke Therapy Academic Industry Roundtable standard. Publication bias was assessed using Egger's test. Results: Eleven trials were included, including 54 experiments with a total of 362 animals involved. CAR immunotherapy significantly improved the survival of animals (HR: 0.25, 95% CI: 0.13–0.37, P

Suggested Citation

  • Yingcheng Wu & Ran Xu & Keren Jia & Hui Shi, 2017. "The efficacy of chimeric antigen receptor (CAR) immunotherapy in animal models for solid tumors: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-11, November.
    • Handle: RePEc:plo:pone00:0187902
    DOI: 10.1371/journal.pone.0187902
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