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Dynamical system modeling to simulate donor T cell response to whole exome sequencing-derived recipient peptides: Understanding randomness in alloreactivity incidence following stem cell transplantation

Author

Listed:
  • Vishal Koparde
  • Badar Abdul Razzaq
  • Tara Suntum
  • Roy Sabo
  • Allison Scalora
  • Myrna Serrano
  • Max Jameson-Lee
  • Charles Hall
  • David Kobulnicky
  • Nihar Sheth
  • Juliana Feltz
  • Daniel Contaifer Jr.
  • Dayanjan Wijesinghe
  • Jason Reed
  • Catherine Roberts
  • Rehan Qayyum
  • Gregory Buck
  • Michael Neale
  • Amir Toor

Abstract

Quantitative relationship between the magnitude of variation in minor histocompatibility antigens (mHA) and graft versus host disease (GVHD) pathophysiology in stem cell transplant (SCT) donor-recipient pairs (DRP) is not established. In order to elucidate this relationship, whole exome sequencing (WES) was performed on 27 HLA matched related (MRD), & 50 unrelated donors (URD), to identify nonsynonymous single nucleotide polymorphisms (SNPs). An average 2,463 SNPs were identified in MRD, and 4,287 in URD DRP (p

Suggested Citation

  • Vishal Koparde & Badar Abdul Razzaq & Tara Suntum & Roy Sabo & Allison Scalora & Myrna Serrano & Max Jameson-Lee & Charles Hall & David Kobulnicky & Nihar Sheth & Juliana Feltz & Daniel Contaifer Jr. , 2017. "Dynamical system modeling to simulate donor T cell response to whole exome sequencing-derived recipient peptides: Understanding randomness in alloreactivity incidence following stem cell transplantati," PLOS ONE, Public Library of Science, vol. 12(12), pages 1-24, December.
    • Handle: RePEc:plo:pone00:0187771
    DOI: 10.1371/journal.pone.0187771
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