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The risk factor of clinical relapse in ulcerative colitis patients with low dose 5-aminosalicylic acid as maintenance therapy: A report from the IBD registry

Author

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  • Tomohiro Fukuda
  • Makoto Naganuma
  • Shinya Sugimoto
  • Kosaku Nanki
  • Shinta Mizuno
  • Makoto Mutaguchi
  • Yoshihiro Nakazato
  • Nagamu Inoue
  • Haruhiko Ogata
  • Yasushi Iwao
  • Takanori Kanai

Abstract

Background: 5-Aminosalicylic acids (5-ASA) are effective for ulcerative colitis (UC) as a maintenance therapy. It is not clear when and how to reduce a dose of 5-ASA after inducing remission. We aimed to investigate the clinical characteristics and evaluate the risk factors of relapse for UC patients receiving 5-ASA. Methods: The medical records of prospectively registered UC patients who received oral 5-ASA as maintenance therapy between January and December 31, 2014, were investigated. The patients’ clinical characteristics in a 2-year follow-up were compared between a relapse group and a remission group. Results: Of 527 UC patients receiving only oral 5-ASA, 390 (74.0%) maintained remission and 137 (26.0%) relapsed during the follow-up period. Multivariable analysis indicated that a shorter duration of disease remission (p

Suggested Citation

  • Tomohiro Fukuda & Makoto Naganuma & Shinya Sugimoto & Kosaku Nanki & Shinta Mizuno & Makoto Mutaguchi & Yoshihiro Nakazato & Nagamu Inoue & Haruhiko Ogata & Yasushi Iwao & Takanori Kanai, 2017. "The risk factor of clinical relapse in ulcerative colitis patients with low dose 5-aminosalicylic acid as maintenance therapy: A report from the IBD registry," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-11, November.
    • Handle: RePEc:plo:pone00:0187737
    DOI: 10.1371/journal.pone.0187737
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