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Incident osteoarthritis and osteoarthritis-related joint replacement surgery in patients with ankylosing spondylitis: A secondary cohort analysis of a nationwide, population-based health claims database

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  • Ming-Chi Lu
  • Chien-Hsueh Tung
  • Chang-Chen Yang
  • Chun-Lung Wang
  • Kuang-Yung Huang
  • Malcolm Koo
  • Ning-Sheng Lai

Abstract

Background: Ankylosing spondylitis (AS) might be associated with an increased risk of secondary osteoarthritis. However, there is a lack of studies assessing its impact on osteoarthritis-related surgery. The aim of this secondary cohort study was to investigate the risk of symptomatic osteoarthritis and osteoarthritis-related surgery, including total hip replacement surgery (THRS) and total knee replacement surgery (TKRS) in patients with AS. Methods: Using the Taiwan’s National Health Insurance Research Database, we identified 3,462 patients with AS between 2000 and 2012. A comparison cohort was assembled consisting of five patients without AS, based on frequency matching for sex, 10-year age interval, and index year, for each patient with AS. Both groups were followed until diagnosis of the study outcomes or the end of the follow-up period. Results: Male patients with AS exhibited a significantly higher incidence of osteoarthritis (adjusted incidence rate ratio [IRR] 1.43; P

Suggested Citation

  • Ming-Chi Lu & Chien-Hsueh Tung & Chang-Chen Yang & Chun-Lung Wang & Kuang-Yung Huang & Malcolm Koo & Ning-Sheng Lai, 2017. "Incident osteoarthritis and osteoarthritis-related joint replacement surgery in patients with ankylosing spondylitis: A secondary cohort analysis of a nationwide, population-based health claims databa," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-9, November.
    • Handle: RePEc:plo:pone00:0187594
    DOI: 10.1371/journal.pone.0187594
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