IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0185761.html
   My bibliography  Save this article

Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium

Author

Listed:
  • Adrien De Voeght
  • Henri Martens
  • Chantal Renard
  • Dolores Vaira
  • Mathieu Debruche
  • Julie Simonet
  • Vincent Geenen
  • Michel Moutschen
  • Gilles Darcis

Abstract

Microbial translocation is now viewed as a central event in the pathogenesis of chronic inflammation during HIV infection. Thymic function failure is another crucial factor involved in HIV disease progression. The goal of this study was to explore the hypothesis of potential links between microbial translocation and thymic function in HIV-1 patients living in Belgium. The extent of microbial translocation was assessed through the measurement of soluble CD14 (sCD14). T-cell receptor excision circles (sjTRECs and dβTRECs) were used as a measure of thymic function. Data were collected from 75 HIV-infected patients. Simple and complex linear regressions were done to analyze the link between these two processes. We found a statistically relevant negative correlation between thymopoiesis (sjTREC) and sCD14 level (p = 0.004). These results suggest a link between thymic function failure, microbial translocation and innate immune activation.

Suggested Citation

  • Adrien De Voeght & Henri Martens & Chantal Renard & Dolores Vaira & Mathieu Debruche & Julie Simonet & Vincent Geenen & Michel Moutschen & Gilles Darcis, 2017. "Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0185761
    DOI: 10.1371/journal.pone.0185761
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185761
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0185761&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0185761?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0185761. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.