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Incidence of DAA failure and the clinical impact of retreatment in real-life patients treated in the advanced stage of liver disease: Interim evaluations from the PITER network

Author

Listed:
  • Loreta A Kondili
  • Giovanni Battista Gaeta
  • Maurizia Rossana Brunetto
  • Alfredo Di Leo
  • Andrea Iannone
  • Teresa Antonia Santantonio
  • Adele Giammario
  • Giovanni Raimondo
  • Roberto Filomia
  • Carmine Coppola
  • Daniela Caterina Amoruso
  • Pierluigi Blanc
  • Barbara Del Pin
  • Liliana Chemello
  • Luisa Cavalletto
  • Filomena Morisco
  • Laura Donnarumma
  • Maria Grazia Rumi
  • Antonio Gasbarrini
  • Massimo Siciliano
  • Marco Massari
  • Romina Corsini
  • Barbara Coco
  • Salvatore Madonia
  • Marco Cannizzaro
  • Anna Linda Zignego
  • Monica Monti
  • Francesco Paolo Russo
  • Alberto Zanetto
  • Marcello Persico
  • Mario Masarone
  • Erica Villa
  • Veronica Bernabucci
  • Gloria Taliani
  • Elisa Biliotti
  • Luchino Chessa
  • Maria Cristina Pasetto
  • Pietro Andreone
  • Marzia Margotti
  • Giuseppina Brancaccio
  • Donatella Ieluzzi
  • Guglielmo Borgia
  • Emanuela Zappulo
  • Vincenza Calvaruso
  • Salvatore Petta
  • Loredana Falzano
  • Maria Giovanna Quaranta
  • Liliana Elena Weimer
  • Stefano Rosato
  • Stefano Vella
  • Edoardo Giovanni Giannini

Abstract

Background: Few data are available on the virological and clinical outcomes of advanced liver disease patients retreated after first-line DAA failure. Aim: To evaluate DAA failure incidence and the retreatment clinical impact in patients treated in the advanced liver disease stage. Methods: Data on HCV genotype, liver disease severity, and first and second line DAA regimens were prospectively collected in consecutive patients who reached the 12-week post-treatment and retreatment evaluations from January 2015 to December 2016 in 23 of the PITER network centers. Results: Among 3,830 patients with advanced fibrosis (F3) or cirrhosis, 139 (3.6%) failed to achieve SVR. Genotype 3, bilirubin levels >1.5mg/dl, platelet count

Suggested Citation

  • Loreta A Kondili & Giovanni Battista Gaeta & Maurizia Rossana Brunetto & Alfredo Di Leo & Andrea Iannone & Teresa Antonia Santantonio & Adele Giammario & Giovanni Raimondo & Roberto Filomia & Carmine , 2017. "Incidence of DAA failure and the clinical impact of retreatment in real-life patients treated in the advanced stage of liver disease: Interim evaluations from the PITER network," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-13, October.
    • Handle: RePEc:plo:pone00:0185728
    DOI: 10.1371/journal.pone.0185728
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