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Effectiveness of beta-blockers depending on the genotype of congenital long-QT syndrome: A meta-analysis

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  • Jinhee Ahn
  • Hyun Jung Kim
  • Jong-Il Choi
  • Kwang No Lee
  • Jaemin Shim
  • Hyeong Sik Ahn
  • Young-Hoon Kim

Abstract

Background: Beta-blockers are first-line therapy in patients with congenital long-QT syndrome (LQTS). Objective: This study sought to determine the differences in effectiveness of beta-blockers on risk reduction according to LQTS genotype. Methods: We searched MEDLINE, EMBASE, and CENTRAL databases to investigate the use of beta-blockers (atenolol, nadolol, propranolol, and metoprolol) in patients with LQTS. Hazard ratio (HR) and relative risk (RR) were extracted or calculated from studies reporting cardiac events (syncope, aborted cardiac arrest (ACA), or sudden cardiac death (SCD)). Results: Among 2,113 articles searched, 10 studies (7 registry-based cohort studies (Cohort) and 3 interrupted time series studies (ITS)) involving 9,727 patients were included. In a meta-analysis using a random-effect model, the use of beta-blocker was associated with significant risk reduction of all cardiac events (HR 0.49, p

Suggested Citation

  • Jinhee Ahn & Hyun Jung Kim & Jong-Il Choi & Kwang No Lee & Jaemin Shim & Hyeong Sik Ahn & Young-Hoon Kim, 2017. "Effectiveness of beta-blockers depending on the genotype of congenital long-QT syndrome: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-13, October.
    • Handle: RePEc:plo:pone00:0185680
    DOI: 10.1371/journal.pone.0185680
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